Table 1.

Comparison of Intraerythrocytic Multiplication Factor (IMF) Values for Different Plasmodium falciparum Strains in Control and Hemoglobinopathic Erythrocytes

Parasite	Hb Type	IMF				Donors, n	Egress Sites, n	P Value
		Mean ± SEM	Median	IQR	Range
3D7	Control	26.68 ± 0.26	27	24–30	16–40	13	237
3D7	AS	27.08 ± 0.25	27	25–30	11–41	3	273	.156
3D7	SS	27.95 ± 0.49	29	25–31	15–40	2	84	.001
3D7	α-thal traita	23.19 ± 0.54	23	19–27	12–32	3	75	<.001
3D7	β-thal trait	23.24 ± 0.57	23	20–26	15–34	3	59	<.001
KN1068–4	Control	24.56 ± 0.39	25	22–27.5	12–34	2	108
KN1068–4	α-thal trait	22.40 ± 0.37	22	20–24	14–34	1	101	<.001
CP803	Control	15.75 ± 0.19	15	14–17	7–28	5	322
CP803	β-thal trait	12.48 ± 0.16	12	11–14	5–19	1	235	<.001

P values were calculated using the Kolmogorov–Smirnov test (comparisons made to control samples).

Abbreviations: 3D7, a laboratory adapted, clonal P. falciparum line; CP803, a short-term adapted, clonal P. falciparum isolate obtained from a Cambodian adult with malaria; Hb, hemoglobin; IQR, interquartile range; KN1068-4, a short-term adapted P. falciparum isolate obtained from a Malian child with malaria; thal, thalassemia.

^a See Supplementary Table 1 for the molecular background of individual donors.