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AUIC values calculated as the ratio of the model simulated moxifloxacin AUC24h values after a standard 400 mg oral dose vs. the theoretical Streptococcus pneumoniae MIC values. Simultaneously the AUIC cut-off values for bacterial eradication as well as suppression of bacterial resistance formation, as proposed in the literature, are shown. (long dashes: AUIC = 100; short dashed lines: AUIC = 200)
