Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 17;78(1):106–117. doi: 10.1111/bcp.12323

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Distribution of post-dose 1 trough concentrations (C_min1) by dose. The box plots represent median (bold line), 25th, and 75th percentiles of the C_min1 distribution. The whiskers represent 5th and 95th percentiles of the distribution. The shaded areas indicate the target trough concentration ranges that maximally inhibit the binding of CTLA-4 to B7.1 (6–20 μg ml⁻¹) and B7.2 (1–3 μg ml⁻¹)