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. 2014 Jan 17;78(1):106–117. doi: 10.1111/bcp.12323

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© 2014 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Ipilimumab AUC_ss vs. (A) baseline LDH levels, (B) renal function status and (C) NCI liver dysfunction group. The box plots represent median (bold line), 25th, and 75th percentiles of the AUC_ss distribution. The whiskers represent 5th and 95th percentiles of the distribution. , individual estimates; , locally weighted smooth line

Inline graphic — Ipilimumab AUC_ss vs. (A) baseline LDH levels, (B) renal function status and (C) NCI liver dysfunction group. The box plots represent median (bold line), 25th, and 75th percentiles of the AUC_ss distribution. The whiskers represent 5th and 95th percentiles of the distribution. , individual estimates; , locally weighted smooth line