Table 3.
True and estimated parameter values for the simulation scenario in which body weight is exponentially correlated with clearance with a slope of 1.5
| Parameter | True value | Estimated subgroup a | Estimated group c |
|---|---|---|---|
| Clearance (CL) | |||
| CL/F = θ1 × (BW/med)** θ2 | |||
| θ1 (coefficient) (l h−1) | 13.8 | 10.7 | 13.7 |
| θ2 (exponent) | 1.5 | 1.31 | 1.60 |
| Volume of distribution (V) (l) | 40.4 | 40.9 | 42.2 |
| Absorption rate constant (Ka) (h−1) | 2.8 | 3.92 | 3.35 |
| Interindividual variability | |||
| ηCL/F | 0.079 | 0.092 | 0.076 |
| ηV/F | 0.056 | 0.022 | 0.036 |
| ηKa/F | 0.331 | 0.241 | 0.185 |
| Residual error (proportional) | 0.03 | 0.002 | 0.003 |