Table 2.
Model parameters (%RSE) for (I) base model estimated in adults [21], (II) base model re-estimated in children and (III) final covariate model in children
| (I) Base model with parameters estimated in adults | (II) Base model with parameters estimated in children | (III) Final covariate model in children | |
|---|---|---|---|
| Objective function value | −10586.8 | −10906.1 | |
| Structural model parameters | |||
| EC50 per VKORC1 | |||
| - G allele (mg l−1) | 1.62 (10) | 2.05 (4.6) | 2.02 (4.3) |
| - A allele (mg l−1) | 0.770 (9.5) | 0.91 (10.4) | 0.997 (9.8) |
| MTT1 (h) | 22.6 (3.3) | 42.7 (18.7) | 37.4 (0.6) |
| MTT2-MTT1 (h) | 87.8 (5.8) | 6.2 (295) | 156 (6.6) |
| MTT2 (h)* | 110 | 48.9 | 193 |
| Hill factor (γ), Emax model | 1.37 (4.9) | 1.37 FIX | 1.37 FIX |
| Age effect on K10 | |||
| - Increase at age 6.3 years (%) | 0.879 (35.5) | ||
| - Half-life, age-effect on K10 (years) | 0.488 (3.9) | ||
| Time effect on EC50 | |||
| - Decrease at time 0 (%) | 61.7 (0.7) | ||
| - Half-life, time-effect on EC50 (h) | 170 (6.8) | ||
| Interindividual variability parameters (%) | |||
| ωEC50 | 32 (4.3) | 36 (6.6) | 33.9 (6.4) |
|
42 (8.3) | 159 (9.9) | 124 (11.3) |
| Residual error parameters (%) | |||
| σINR | 18 (1.7) | 25.4 (0.3) | 24.9 (0.3) |
*
MTT2 was not estimated but derived from MTT1 and MTT2-MTT1.