Table 2. Summary of germline mutations, somatic mutations, and methylation of BRCA1, BRCA2 and RAD51C.

		Gene, n
	N Tested	BRCA1	BRCA2	RAD51C	Combined HRD
Germline deleterious mutation	899	32	28	26	83
Somatic deleterious mutation	279	6	4	0	10
Methylated	482	45	-	7	52
No deleterious mutation, not methylated	NA	237	261	263	NA
No deleterious germline mutation, unknown somatic mutation and/or tumor methylation status	NA	592	606	604	NA
Not methylated, germline and somatic mutation status unknown	NA	151	164	163	NA
Total		1063	1063	1063	143

Deleterious mutations were frame shift insertion/deletion, splice site, rare missense supported by multiple methods to be damaging; NA, not applicable; one case carried germline deleterious mutations for both BRCA2 and RAD51C, and two patients carried germline deleterious mutations for BRCA1 and RAD51C, thus the combined number of germline deleterious mutation carriers is less than the sum of mutation carriers for each gene; one case carried a RAD51C germline deleterious mutation and methylated for BRCA1 and another case carried a BRCA2 somatic deleterious mutation and methylated for BRCA1, thus the total number of patients with a HRD phenotype is less than the sum of germline mutation carriers and patients with a somatically mutated or methylated gene.