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. 2014 Sep 19;8:170. doi: 10.3389/fnsys.2014.00170

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Copyright © 2014 Krause, Raz, Uhlrich, Smith and Banks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evoked UP states. (A) Simultaneous whole-cell recordings from a layer 4 cell (gray) and a layer 5 cell (black) on five consecutive trials in response to single stimulation pulse applied to TC afferents (vertical dotted line) show that UP states are network events with variable duration between trials but consistent time course between cells on a given trial. Scale bar: 50 ms, 10 mV. Action potentials are truncated. (B) Multiunit activity (filtered 0.3–3 kHz) from multichannel recordings similar to Figure 1 shows the UP state as a burst of high frequency activity occurring on multiple channels, but beginning in layer 5 (top). Vertical dotted lines mark stimulus times. The smoothed MUA power in layer 5 is used to detect UP states (shaded gray area, bottom) on single trials. Horizontal dashed lines represent the boundaries used to detect UP state onset and offset (see Materials and Methods).