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. 2014 Sep 19;8:301. doi: 10.3389/fnins.2014.00301

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Copyright © 2014 Gwynne, Clarke, Furness and Bornstein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An hypothesis about the sequence of mechanisms by which exogenous or endogenous 5-HT in the lumen enhances propulsion in the guinea-pig ileum. 5-HT acts on 5-HT₄ receptors on enterochromaffin cells to release more 5-HT, this higher concentration of 5-HT then excites mucosal terminals of myenteric AH neurons via 5-HT₃ receptors. The myenteric AH neurons then release tachykinins to enhance the excitability of distension-sensitive myenteric AH neurons via NK₃ receptors.