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(A) Exploratory activity of novel and familiar objects during T2, (B) discrimination index and (C) total exploration time in NOR2 test. Animals received i.c.v. injection of vehicle (5 μl; sham) or sAβ (4 μM, 5 μl) 2 h before training (T1) and tested 24 h later (T2). Data are expressed as mean ± SEM of total time in s (n = 6 sham; n = 12 sAβ-treated group). (Two-way RM ANOVA followed by Bonferroni’s multiple comparisons test ***P < 0.001 vs. familiar object; t-test *P < 0.05 vs. sham).
