Figure 4. Comparative tractography study between the two hemispheres in the seven cases of low-grade glioma.

Cases LGG1 and LGG5: Estimation of the fiber tracts between the two target regions in the healthy hemisphere, and comparison with the contralateral affected architecture. The superior bundle of Cingulum, reconstructed in the homologous region, resulted dorsally displaced in the pathological hemisphere in case LGG1, while its inferior pathway was not identified at all in the lesioned area. The inferior Fronto-Occipital Fasciculus, tracked in patient LGG5, was displaced as well. Cases LGG2, LGG3, LGG4, LGG6, and LGG7: estimation of the fiber tracts between the main target and the dilated region homologous to the tumor in the healthy hemisphere; comparison with the contralateral affected architecture. The Superior Longitudinal Fascicle identified in case LGG2 could not be tracked in the affected hemisphere. In patient LGG3, the inferior bundle of the Arcuate Fasciculus that connected the homologous region to the target ROI resulted destroyed in the pathological area. The Cerebellar tracts tracked in patients LGG4 and LGG6 appeared disrupted by the infiltrating tumor mass. Finally, in patient LGG7 the inferior part of Arcuate fasciculus, reconstructed in the healthy hemisphere resulted mostly destroyed in the contralateral area.