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. 2014 Sep 9;2:e497. doi: 10.7717/peerj.497

Figure 5. Comparative tractography study between the two hemispheres in the four cases of high-grade gliomas.

Figure 5

Cases HGG1, HGG2, HGG3, and HGG4: estimation of the fiber tracts between the main target and the dilated region homologous to the tumor in the healthy hemispheres; comparison with the contralateral lesioned architecture. Tumor infiltration can be clearly seen in all the four cases. The Superior Longitudinal Fascicle in the affected hemisphere was largely disrupted in both patients HGG1 and HGG3. The Arcuate Fasciculus connecting the homologous area and the target ROI in the healthy hemisphere of case HGG2, resulted almost entirely destroyed in the tumor area. In addition, tractography in patient HGG4 demonstrated the huge loss of fiber tracts belonging to the Inferior Fronto-Occipital Fasciculus and the Cingulum reconstructed in the healthy brain contralateral area.