Table 1. Ligand Optimizationa.
a
Reaction conditions: 1.0 equiv of 8a, 1.2 equiv of 12, 2.4 equiv of LiOtBu, 4 mol % Pd(OAc)2, 8 mol % ligand, PhCF3 (0.1 M), 100 °C, 16 h.
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