Table 1. Antimicrobial Activity of Cyclothiazomycins B and C toward a Panel of Diverse Bacteria and Fungi.
| MICb |
||
|---|---|---|
| speciesa | cyclothiazomycin B | cyclothiazomycin C |
| Bacillus anthracis | 1 | 1 |
| Bacillus subtilis | 2 | 4 |
| Enterococcus faecalis | 32 | 32–64 |
| Listeria monocytogenes | 8 | 16 |
| Staphylococcus aureus | 4 | 16 |
| Escherichia coli | 64 | >64 |
| Neisseria sicca | >64 | >64 |
| Pseudomonas putida | >64 | >64 |
| Aspergillus niger | >64 | >64 |
| Fusarium virguliforme | 64 | >64 |
| Saccharomyces cerevisiae | 64 | >64 |
| Talaromyces stipitatus | 64 | >64 |
a
The top five species are Gram-positive bacteria from the Firmicutes phylum. The next three species are Gram-negative bacteria from the Proteobacteria phylum. The lowest 4 species are fungi from the Ascomycota phylum.
b
All minimum inhibitory concentrations (MIC) were determined by the microbroth dilution method and are presented in μg/mL.