Table 1.

Summary of pattern enrichment results for each dataset (WGGA/ACUK)

Dataset	Pattern	Total genes	Total genes (others)	Pattern per KB	Pattern per KB (others)	Difference of means	Permutation P-value	T-test P-value	Wilcoxon P-value	Effect size
Ascano (PAR-CLIP)	ACUK	6658	11 751	14.09	11.77	2.32	<1 × 10−6	1.82 × 10−113	2.62 × 10−140	0.358
	WGGA	6658	11 751	19.68	18.65	1.03	<1 × 10−6	6.09 × 10−17	4.22 × 10−21	0.128
Ascano (RIP-CHIP)	ACUK	921	17 488	11.75	12.66	−0.91	4.4 × 10−5	1.24 × 10−7	0.0024	0.140
	WGGA	921	17 488	20.45	18.95	1.50	<1 × 10−6	5.01 × 10−10	3.23 × 10−15	0.187
Brown	ACUK	354	18 055	11.22	12.64	−1.41	6.5 × 10−5	1.29 × 10−6	1.25 × 10−5	0.219
	WGGA	354	18 055	19.08	19.02	0.06	0.8903	0.8730	0.4273	0.007
Darnell	ACUK	807	17 602	11.83	12.65	−0.81	0.0005	0.0002	5.68 × 10−5	0.126
	WGGA	807	17 602	19.76	18.99	0.77	0.0077	0.0094	0.0062	0.096
Common B_D_A-PAR	ACUK	135	18 274	11.97	12.62	−0.65	0.2443	0.2003	0.2166	0.100
	WGGA	135	18 274	20.05	19.02	1.04	0.1349	0.1170	0.0959	0.129
Common D_A-PAR	ACUK	516	17 893	12.40	12.62	−0.22	0.4464	0.4111	0.6597	0.034
	WGGA	516	17 893	19.73	19.00	0.73	0.0431	0.0421	0.0134	0.090
Common B_D	ACUK	180	18 229	11.34	12.62	−1.28	0.0084	0.0027	0.0025	0.198
	WGGA	180	18 229	19.59	19.02	0.57	0.3432	0.3040	0.2264	0.071
Common B_D_A-RIP	ACUK	53	18 356	11.82	12.61	−0.79	0.3721	0.2810	0.4739	0.122
	WGGA	53	18 356	21.64	19.02	2.63	0.0177	0.0082	0.0023	0.327
SFARI	ACUK	517	17 892	13.72	12.58	1.14	0.0001	0.0001	6.91 × 10−6	0.177
	WGGA	517	17 892	20.06	18.99	1.06	0.0031	0.0030	0.0007	0.132
MR_OMIM	ACUK	803	17 606	13.45	12.57	0.88	0.0002	0.0002	7.92 × 10−5	0.137
	WGGA	803	17 606	20.00	18.98	1.02	0.0004	0.0007	0.0011	0.127

Each dataset was evaluated for the ACUK and WGGA sequences by several statistical metrics.

Common B_D_A-PAR reflects the list of 135 overlapping genes in the Brown, Darnell and Ascano PAR-CLIP data; Common D_A-PAR reflects the list of 516 overlapping genes in the Darnell and Ascano PAR-CLIP data; Common B_D reflects the list of 180 overlapping genes in the Brown and Darnell data; Common B_D_A-RIP reflects the list of 53 overlapping genes in the Brown, Darnell and Ascano RIP-Chip data.