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. 2014 Sep 18;10(9):e1003851. doi: 10.1371/journal.pcbi.1003851

Figure 1. The PAM50 gene signatures and their association with clinical information in the training data set.

Figure 1

A, The heatmap of the log2 transformed gene expression for PAM50 signatures. Green and red colors represent higher and lower expression levels, respectively. The samples are further categorized into two major groups based on the hierarchical clustering. The p-values of the clinical features such as ER, PG, P53, Grade, lymph node (LN) and dichotomized groups with relation to relapse status are calculated using Chi-square tests. B–E, Kaplan Meier survival estimates of relapse free survivals according to major clinical features: (B) Lymph node status, (C) Grade, (D) P53 mutation status and (E) Tumor size. P-values are calculated using Wilcoxon log-rank tests and (+) denotes the censored observations in the study.