Table 2. Selected features in the models.
Features | Coefficients | Hazard Ratio | p-values in univariate COX-PH model |
Pathway-based genomic model | |||
KEGG_MELANOGENESIS* | 1.075908 | 2.93266 | 0.00188 |
BIOCARTA_SRCRPTP_PATHWAY* | 0.914698 | 2.49602 | 1.01e-7 |
BIOCARTA_AKAP13_PATHWAY* | 0.828364 | 2.28957 | 0.00351 |
BIOCARTA_RARRXR_PATHWAY* | 0.670795 | 1.95579 | 9.58e-6 |
BIOCARTA_VIP_PATHWAY* | 0.635108 | 1.88723 | 2.15e-5 |
KEGG_FATTY_ACID_METABOLISM * | 0.520653 | 1.68313 | 2.53e-6 |
BIOCARTA_G1_PATHWAY* | 0.520446 | 1.68278 | 2.66e-6 |
KEGG_LINOLEIC_ACID_METABOLISM | 0.368615 | 1.44573 | 3.55e-4 |
KEGG_LYSOSOME | 0.300587 | 1.35065 | 2.2e-6 |
BIOCARTA_P53_PATHWAY* | 0.239062 | 1.27006 | 8.74e-4 |
BIOCARTA_PYK2_PATHWAY* | 0.158405 | 1.17164 | 1.29e-4 |
BIOCARTA_GABA_PATHWAY | 0.139229 | 1.14939 | 0.0162 |
BIOCARTA_FEEDER_PATHWAY | 0.110334 | 1.11665 | 0.0218 |
BIOCARTA_RNA_PATHWAY* | 0.037978 | 1.03871 | 7.67e-5 |
BIOCARTA_IL5_PATHWAY | 0.012039 | 1.01211 | 0.00895 |
Clinical model | |||
Lymph Node Status* | 0.375874 | 1.456264 | 4.46e-7 |
Tumor Size* | 0.270893 | 1.311135 | 6.03e-7 |
Grade | 0.126814 | 1.135206 | 4.92e-4 |
P53 | 0.043517 | 1.044478 | 0.0171 |
*: these pathways and clinical parameters are also selected by the combined model.