Table 3. Non-compartmental and two-compartmental analysis of pharmacokinetic parameters for a wild-type IgG4, glycosylated monovalent IgG4 and aglycosylated monovalent IgG4.
| Non-compartmental analysis | ||||
|---|---|---|---|---|
| Parameter | Unit | Mono agly IgG4 | Mono gly IgG4 | WT IgG4 |
| Half-life | days | 0.86 | 0.86 | 13.89 |
| Cmax | ug/ml | 293.26 | 244.71 | 262.31 |
| AUCINF | day*ug/ml | 131.83 | 178.93 | 1896.33 |
| Clearance | ml/day/kg | 75.85 | 55.89 | 5.27 |
| Two-compartmental modeling | ||||
| Half-life | days (S.D.) | 0.85 (0.08) | 0.87 (0.08) | 13.36 (4.12) |
| Clearance | ml/day/kg (S.D.) | 119.6 (12.1) | 103.9 (11.3) | 5.32 (1.1) |