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Figure 9. Representative reverse phase LC/MS extracted ion chromatogram of acidic tryptic digests of mAb-1 recovered from serum showing the EIC’s of HC99–130 tryptic peptide (MW = 3583.5 Da) and the corresponding tryptic peptide containing the succinimide (Asu) modification (MW = 3566.5 Da) and the Asp and iso-Asp modification (MW 3584.5 Da).
