Table 1.
Characteristics of study participants at baseline by randomised treatment
| Placebo | 0.45 g/day | 0.9 g/day | 1.8 g/day | P* | |
|---|---|---|---|---|---|
| n = 70 | n = 80 | n = 80 | n = 80 | ||
| Gender | |||||
| Male, n (%) | 31, 44 | 30, 37.5 | 30, 37.5 | 29, 36 | |
| Female, n (%) | 39, 56 | 50, 62.5 | 50, 62.5 | 51, 64 | |
| Ethnicity | |||||
| White, n (%) | 57, 81.4 | 64, 80.0 | 64, 80.0 | 69, 86.25 | |
| Far Eastern, n (%) | 6, 8.6 | 4, 5.0 | 5, 6.25 | 1, 1.25 | |
| S. Asian, n (%) | 3, 4.3 | 6, 7.5 | 8, 10.0 | 1, 1.25 | |
| Black, n (%) | 2, 2.85 | 3, 3.75 | 0, 0.0 | 4, 5.0 | |
| Other, n (%) | 2, 2.85 | 3, 3.75 | 3, 3.75 | 5, 6.25 | |
| Age (years) | 55.4 ± 6.9 | 55.1 ± 6.8 | 55.2 ± 6.6 | 55.1 ± 6.7 | 0.99 |
| BMI (kg/m2) | 26.1 ± 3.7 | 25.1 ± 3.9 | 26.2 ± 4.0 | 25.2 ± 3.5 | 0.17 |
| Waist circumference (cm) | 89.5 ± 11.7 | 87.3 ± 11.8 | 89.4 ± 11.9 | 88.0 ± 11.0 | 0.60 |
| Plasma lipids (mmol/L) | |||||
| TC | 5.4 ± 1.0 | 5.4 ± 1.1 | 5.4 ± 0.9 | 5.4 ± 1.0 | 0.94 |
| HDL-C | 1.6 ± 0.5 | 1.6 ± 0.4 | 1.7 ± 0.5 | 1.7 ± 0.5 | 0.26 |
| LDL-C | 3.3 ± 0.8 | 3.2 ± 0.8 | 3.2 ± 0.8 | 3.2 ± 0.7 | 0.79 |
| TGa | 1.2 ± 0.5 | 1.1 ± 0.5 | 1.1 ± 0.4 | 1.1 ± 0.5 | 0.96 |
Data are presented for subjects randomised to treatment groups for whom DNA was available (n = 310). Measurements taken at baseline after 4-week run-in on normal diet with olive oil placebo supplement are shown for each randomised treatment group: placebo and EPA and DHA (1.51:1) at the daily doses shown. Values are n (%) for gender and ethnic groups, or mean ± SD for all other variables except TG
BMI body mass index, HDL-C high-density-lipoprotein cholesterol, LDL-C low-density-lipoprotein cholesterol, TC total cholesterol, TG triglyceride
* Significance of differences between treatment groups assessed by one-way ANOVA. P value for difference in age, adjusted for BMI, gender and ethnicity; for differences in BMI and waist circumference, adjusted for age, gender and ethnicity; for differences in plasma lipid concentrations, adjusted for BMI, age, gender and ethnicity
aTG data not normally distributed and presented as the geometric mean ± SE