Table 5.
Associations between parameters of habitual physical activity and SNPs in PPARD and PPARGC1A obtained by meta-analysis
| Phenotype | Gene | SNP | Genotype/Haplotype | Beta | P value | Heterogeneity |
|---|---|---|---|---|---|---|
| HPA | PPARD | rs2267668 | AG | −384.3 | 0.005 | 0.41 |
| GG | −684.6 | 0.057 | 0.15 | |||
| PPARD | rs2076168 | AC | −247.5 | 0.053 | 0.68 | |
| CC | −801.1 | 0.006 | 0.43 | |||
| PPARD | Haplotype | AA and GC | −348.4 | 0.017 | 0.96 | |
| High | PPARGC1A | rs8192678 | GA | −0.139 | 0.27 | 0.49 |
| AA | 0.671 | 0.001 |
HPA, habitual physical activity in Mcnts/day; %High, the time spent on high-intensity physical activity in min/d; for rs2267668 and rs2076168 in PPARD, AA carriers are the reference group; for the haplotype analysis, AA AA and AA AC haplotype carriers are the reference group; for rs8192678 in PPARGC1A, GG carriers are the reference group. High was natural log transformed. Heterogeneity refers to the P value of Q statistic