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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Biomaterials. 2014 Jun 24;35(28):8049–8064. doi: 10.1016/j.biomaterials.2014.05.084

Fig. 11.

Fig. 11

Summary of immunohistochemical assessment following microelectrode implantation. (A) Time course of neuroinflammatory markers and neurodegeneration following microelectrode implantation demonstrates no correlation between IBA1+, CD68+ or IgG + immunoreactivity and neuronal dieback. However, GFAP+ immunoreactivity was highest at two and sixteen weeks, the same time points we observed neurodegeneration. (B) We observed a temporal correlation between increased CFP+ immunoreactivity and neurodegeneration following microelectrode implantation. (C) In evaluating co-localization of activated macrophages and activated microglia within the CD68+ population, we did not observe a correlation between either cell type (activated microglia or activated macrophages) and neurodegeneration. (D) In evaluating the co-localized population of macrophage versus microglia within the total IBA1+ population, we observed a correlation between macrophages, but not microglia and neuronal dieback.