. Author manuscript; available in PMC: 2014 Sep 19.

Published in final edited form as: Acad Radiol. 2014 Feb;21(2):223–231. doi: 10.1016/j.acra.2013.11.014

Table 2.

Comparison of different analysis methods with various initial time points after the pyruvate peak

^*Methods	Tumor	1st		2nd		3nd		4th
^*Methods	Tumor	k⁺(s⁻¹)	k⁻(s⁻¹)	k⁺(s⁻¹)	k⁻(s⁻¹)	k⁺(s⁻¹)	k⁻(s⁻¹)	k⁺(s⁻¹)	k⁻(s⁻¹)
DE	231	0.061 ± .022	0.026 ± .011	0.056 ± .015	0.022 ± .006	0.062 ± .012	0.028 ± .010	0.069 ± .014	0.034 ± .016
	MCF-7	0.109 ± .039	0.025 ± .011	0.108 ± .042	0.025 ± .012	0.101 ± .029	0.023 ± .011	0.101 ± .037	0.023 ± .012
	P	0.096	0.98	0.081	0.73	0.067	0.54	0.18	0.36
QR	231	0.065 ± .014	0.029 ± .010	0.062 ± .008	0.028 ± .012	0.067 ± .005	0.033 ± .017	0.072 ± .008	0.037 ± .021
	MCF-7	0.093 ± .006	0.022 ± .007	0.090 ± .005	0.021 ± .008	0.086 ± .010	0.020 ± .011	0.087 ± .012	0.020 ± .012
	P	0.060	0.38	0.010	0.45	0.028	0.34	0.12	0.30
RF	231	0.057 ± .010	0.024 ± .008	0.054 ± .008	0.022 ± .011	0.058 ± .005	0.026 ± .015	0.060 ± .004	0.028 ± .018
	MCF-7	0.086 ± .004	0.019 ± .007	0.084 ± .005	0.018 ± .007	0.081 ± .009	0.018 ± .009	0.060 ± .042	0.014 ± .014
	P	0.029	0.47	0.012	0.62	0.0081	0.48	0.99	0.32

DE: differential equation fit; QR: q-ratio fit; RF: ratio-fit. Ratio refers to the lactate to pyruvate ratio. The k⁺ and k⁻ refer to the forward and reverse rate constant of the LDH reaction, respectively.