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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Sci Transl Med. 2013 Nov 13;5(211):211ra156. doi: 10.1126/scitranslmed.3006534

Fig. 2. Dysregulated UPR expression in the β cells of human T1D patients.

Fig. 2

(A and B) Pancreatic sections from nondiabetic (Ctrl) and diabetic female patients were grouped and costained with either (A) anti-ATF6 (red) and anti-insulin (green) or (B) anti-sXBPI (red) and anti-insulin (green). The cell nuclei were counterstained with DAPI (blue). (C to E) Relative fluorescence intensity (RFI) of (C) insulin, (D) sXBPI, and (E) ATF6 in the pancreatic sections was calculated on 15 to 25 islets per time point. All data are presented as means ± SEM, with statistical analysis performed by one-way ANOVA (***P < 0.001; **P < 0.005; *P < 0.05).