Table 1. Information on the T1D and control nondiabetic donors.
Pancreatic sections were obtained from nPOD for immunofluorescence analysis of UPR mediators.
| Patient | Age (years) |
Sex | Ethnicity | Duration of diabetes (years) |
AutoAb | Histology |
|---|---|---|---|---|---|---|
| Ctrl | 0.5 | Female | African American | N/A | Negative | Normal islet |
| Ctrl | 2.9 | Male | African American | N/A | Negative | Normal islet |
| Ctrl | 17.8 | Male | Caucasian | N/A | Negative | Normal islet, few with vascular stasis |
| Ctrl | 19.2 | Male | Caucasian | N/A | Negative | Normal islet |
| Ctrl | 32 | Female | Caucasian | N/A | Negative | Normal islet, low Ki67 |
| Ctrl | 59 | Female | Caucasian | N/A | Negative | Normal islet |
| T1D | 13.1 | Female | Caucasian | 1 | mlAA+ | lns+ (reduced)/Gluc+ islets; insulitis |
| T1D | 33.9 | Female | Caucasian | 4 | Negative | lns+/Gluc+ islets; increased acinar Ki67 |
| T1D | 14.2 | Male | Caucasian | 4 | mlAA+ | lns+ islets in lobules with moderate to severe adipose infiltrates |
| T1D | 31.2 | Male | Caucasian | 5 | GADA+, IA2A+, ZnT8A+, mlAA+ |
lns+/Gluc+ islets (much decreased); insulitis; chronic pancreatitis |
| T1D | 22.8 | Female | Caucasian | 7 | IA-2A+, mlAA+ | lns+ islet (few); occ. Ki67+ islet cell; insulitis |
| T1D | 22.9 | Male | African American | 7 | No serum available | lns+ islet of various sizes; acinar atrophy and fibrosis |
| T1D | 18.8 | Female | Caucasian | 8 | IA-2A+, ZnT8A+ | lns+ islet in occ. lobule, lns−/Gluc+ islet |
| T1D | 20.3 | Male | Caucasian | 13 | mlAA+ | lns+ (very reduced)/Gluc+ variable within lobules, islet atrophy |
| T1D | 31.4 | Male | Hispanic | 15 | Negative | lns+ islet; mild to moderate chronic pancreatitis |
| T1D | 50 | Female | Caucasian | 20 | mlAA+ | lns+ islet, insulitis, lns−/Gluc+ islets |
Ins, insulin; Gluc, glucagon; Ab, antibody; N/A, not applicable.