Table 2.
Protein and metabolic measures in internal capsule in schizophrenia and control samples. The MBP assay did not provide reliable data in 3 control samples; these were eliminated from the analysis. Myelin, astrocyte and axonal markers represent immunoreactivity at a standardized total protein concentration. Metabolic marker concentration is expressed as mmol per kg wet weight of tissue used. Effect sizes have positive values if the marker was present at a lower level in schizophrenia samples than in control samples.
| Control | Schizophrenia | F value | P value | Effect size | |
|---|---|---|---|---|---|
| Mean +/− SD (n) | Mean +/− SD (n) | ||||
| Myelin markers | |||||
| MBP dorsal | 0.085+/−0.033 (10) | 0.105+/−0.030 (15) | 2.500 | 0.128 | −0.63 |
| MBP-ventral | 0.103+/−0.024 (10) | 0.103+/−0.026 (15) | 0.001 | 0.975 | 0.01 |
| Astrocyte marker | |||||
| GFAP-dorsal | 0.282+/−0.081 (13) | 0.294+/−0.036 (15) | 0.016 | 0.900 | −0.19 |
| GFAP ventral | 0.288+/−0.089 (13) | 0.307+/−0.057 (15) | 0.497 | 0.487 | −0.25 |
| Axonal markers | |||||
| SNAP-25-dorsal | 0.974+/−0.257 (13) | 0.923+/−0.307 (15) | 0.225 | 0.639 | 0.18 |
| SNAP-25-ventral | 1.188+/−0.303 (13) | 1.113+/−0.260 (15) | 0.509 | 0.482 | 0.27 |
| PNF-dorsal | 1.359+/−0.174 (13) | 1.357+/−0.380 (15) | 0.347 | 0.561 | 0.01 |
| PNF-ventral | 1.462+/−0.106 (13) | 1.438+/−0.118 (15) | 0.338 | 0.566 | 0.21 |
| Metabolic markers | |||||
| Myo-inositol (2CH, 4.05 ppm) | 10.11+/−2.26 (13) | 8.66+/−3.67 (15) | 1.534 | 0.227 | 0.48 |
| Glycerophosphorylcholine (choline moiety, N(CH3)3, 3.21 ppm) | 1.19+/−0.43 (13) | 1.18+/−0.47 (15) | 0.021 | 0.887 | 0.02 |
| Phosphorylcholine (N(CH3), 3.21 ppm) | 1.44+/−0.26 (13) | 1.39+/−0.50 (15) | 0.130 | 0.721 | 0.13 |
| Choline (N(CH3)3, 3.19 ppm) | 0.87+/−0.30 (13) | 0.67+/−0.36 (15) | 2.508 | 0.125 | 0.60 |
| Creatine/phosphocreatine (N(CH3), 3.03 ppm) | 8.04+/−1.80 (13) | 7.34+/−2.10 (15) | 0.882 | 0.356 | 0.36 |
| Succinate (2CH2, 2.40 ppm) | 0.90+/−0.34 (13) | 0.85+/−0.29 (15) | 0.080 | 0.779 | 0.16 |
| N-acetylaspartylglutamate (acetyl moiety, 2CH3, 2.04 ppm) | 3.98+/−1.33 (13) | 3.90+/−1.42 (15) | 0.045 | 0.834 | 0.06 |
| N-acetylaspartate (acetyl moiety, 2CH3, 2.01 ppm) | 3.94+/−1.08 (13) | 3.40+/−1.06 (15) | 1.808 | 0.190 | 0.50 |
| Acetate (2CH3, 1.90 ppm) | 4.32+/−1.27 (13) | 3.76+/−1.51 (15) | 1.128 | 0.298 | 0.40 |
| Alanine (3CH3, 1.47 ppm) | 3.50+/−1.09 (13) | 2.67+/−0.81 (15) | 4.995 | 0.034 | 0.86 |
| Lactate (3CH3, 1.31 ppm) | 22.14+/−1.45 (13) | 18.02+/−4.76 (15) | 4.325 | 0.048 | 1.17 |