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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Sci Transl Med. 2012 Feb 8;4(120):120ra15. doi: 10.1126/scitranslmed.3002865

Fig. 5.

Fig. 5

fMRI results for initially injected eyes in response to high- and medium-contrast stimuli at FO baseline, before injection of the contralateral eyes. (A and B) CH12’s fMRI results for the high- and medium-contrast stimuli showed bilateral activation. (C and D) CH11 showed activation to the high-contrast stimuli (C) but did not respond to medium-contrast stimuli (D). (E and F) Similar to CH11, NP01 responded to the high-contrast but not to the medium-contrast stimulus. The lower cortical activation for NP01 may be due to the fact that subject received the lowest dose of AAV2-hRPE65v2 for her initial subretinal injection and that subject is a chronic smoker (smoking is known to abate cortical blood flow and thus the fMRI signal).