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. Author manuscript; available in PMC: 2015 Jul 2.
Published in final edited form as: Neuron. 2014 Jul 2;83(1):189–201. doi: 10.1016/j.neuron.2014.05.018

Figure 2. Indelible, Specific Labeling of Arc+ Cells following Context Exposure and Contextual Fear Conditioning.

Figure 2

(A) Experimental design. Mice that were dark housed for 3 days following the TAM injection had the least number of EYFP+ DG cells.

(B) Experimental design to assess the impact of context exposure and one-shock CFC on behavior and cell labeling. Mice exposed to the context without a foot shock did not freeze, whereas mice administered a one-shock CFC paradigm froze approximately 20% of the time.

(C–J) The numbers of EYFP+, Arc+, and c-fos+ cells were assessed in both conditions. The number of EYFP+ cells increased with context exposure and with one-shock CFC from the number of EYFP+ cells labeled in the home cage. n = 4–7 mice per group. Error bars represent ± SEM.

See also Figure S2.