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. Author manuscript; available in PMC: 2015 Jul 2.
Published in final edited form as: Neuron. 2014 Jul 2;83(1):189–201. doi: 10.1016/j.neuron.2014.05.018

Figure 7. Social Defeat Causes Impairments in One-Shock CFC and CA3 Reactivation.

Figure 7

(A) Mice were socially defeated (SD) for 2 weeks. Ten days following the end of SD, mice were administered a one-shock CFC paradigm, re-exposed to context A 5 days later, and sacrificed 1 hr later.

(B) Context-elicited freezing was significantly reduced in SD mice when compared with Ctrl mice (F(1,18) = 11.717, p < 0.01).

(C and D) In the DG, (C) the number of EYFP+ (p = 0.69) and (D) Arc+ cells (p = 0.10) did not differ between Ctrl and SD mice.

(E) Ctrl and SD mice had a comparable percent of colabeled EYFP+/Arc+ DG cells (p = 0.63).

(F) Representative image of the immunohistochemistry in the DG. The scale bar represents 100 μm.

(G and H) In CA3, the number of (G) EYFP+ (p = 0.45) and (H) c-fos+ (p = 0.33) cells did not differ between the groups.

(I) SD mice exhibited a significantly smaller percent of colabeled EYFP+/c-fos+ CA3 cells than did Ctrl mice (p < 0.05).

(J) Representative image of immunohistochemistry in CA3. The scale bar represents 100 μm. n = 4–10 mice per group. *p < 0.05, **p < 0.01. Error bars represent ± SEM.

See also Figure S6.