Table 1.
Morphometric and hemodynamic parameters of MCD−/− survivor mice.
| Adult MCD+/+ (n = 6 F + 3 M) |
Adult MCD−/− (n = 6 F + 3 M) |
P value | |
|---|---|---|---|
| Age (weeks) | 21 ± 2 | 21 ± 2 | 0.81 |
| Organ weights | |||
| Body weight (g) | 28.2 ± 1.7 | 29.5 ± 2.7 | 0.69 |
| LV/body weight (mg/g) | 2.72 ± 0.10 | 3.42 ± 0.20 | 0.006 |
| RV/body weight (mg/g) | 0.79 ± 0.10 | 0.99 ± 0.06 | 0.007 |
| Lung/body weight (mg/g) | 4.8 ± 0.8 | 4.8 ± 1.2 | 0.98 |
| Liver weight/body weight (mg/g) | 42.9 ± 1.4 | 41.8 ± 1.5 | 0.63 |
| Echocardiography | |||
| End diastolic area (mm2) | 9.3 ± 0.4 | 10.6 ± 0.6 | 0.10 |
| End systolic area (mm2) | 3.2 ± 0.5 | 4.1 ± 0.8 | 0.39 |
| Fractional area change (%) | 66 ± 4 | 63 ± 5 | 0.65 |
| Myocardial CSA (mm2) | 10.8 ± 0.5 | 13.1 ± 0.7 | 0.02 |
| PAAT (ms) | 18.1 ± 1.3 | 17.7 ± 1.4 | 0.86 |
| Hemodynamics | |||
| Heart rate (bpm) | 505 ± 16 | 493 ± 20 | 0.66 |
| LV systolic pressure (mm Hg) | 98 ± 2 | 96 ± 2 | 0.50 |
| LV end-diastolic pressure (mm Hg) | 6 ± 0.7 | 8 ± 0.9 | 0.12 |
| dP/dtmax (mm Hg/s) | 9929 ± 483 | 7769 ± 514 | 0.007 |
| dP/dtmin (mm Hg/s) | − 9270 ± 589 | − 7105 ± 995 | 0.08 |
| Tau (ms) | 6.9 ± 0.4 | 9.1 ± 0.8 | 0.04 |
| Stimulated dP/dtmax (mm Hg/s) | 13895 ± 957 | 10505 ± 1045 | 0.03 |
LV — left ventricular, RV — right ventricular, CSA — cross sectional area, and PAAT — pulmonary artery acceleration time. All values are mean ± SEM. Comparisons were made by Student's t-test. Stimulated dP/dt denotes value obtained during maximal stimulation with dobutamine 16 ng/g BWt/min.