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Kinesin-driven gliding velocity of GMPCPP microtubules in the presence or absence of microtubule-targeting drugs.
| Condition | Gliding velocity (±SEM) | % change | # of MTs |
|---|---|---|---|
| Control | 27.55 ± 0.56 μm/min | – | 30 |
| Eribulin (10 μM) | 26.14 ± 0.82 μm/min | −5% | 30 |
| Vincristine (10 μM) | 23.86 ± 0.87 μm/min** | −13% | 30 |
| Paclitaxel (10 μM) | 28.67 ± 0.77 μm/min | 4% | 50 |
| Ixabepilone (10 μM) | 22.99 ± 0.76 μm/min** | −17% | 30 |
ANOVA (P < 0.022) followed by Dunnett's post-test, P < 0.01.
