Table 1.
Baseline characteristics of 500 mcg and 1000 mcg arms (mean ± SD unless noted).
| Variable | Groups A and B 500 mcg (n=30) | Groups C and D 1000 mcg (n=29) | p-value |
|---|---|---|---|
|
| |||
| Gender | |||
| Male | 11 (36.7%) | 10 (34.5%) | 1.00 |
|
| |||
| Age | |||
| Years | 54.7 ± 10.6 | 59.3 ± 13.3 | 0.15 |
|
| |||
| Anthropometric Measures | |||
| Weight (lb) | 201.1 ± 30.6 | 203.2 ± 50.9 | 0.84 |
| Waist Circumference (cm) | 107.2 ± 7.9 | 110.4 ± 15.8 | 0.41 |
| BMI (kg/m2) | 33.4 ± 6.1 | 32.7 ± 5.6 | 0.64 |
|
| |||
| Metabolic Syndrome (1) | |||
| Yes | 14 (46.7%) | 19 (65.5%) | 0.19 |
|
| |||
| Blood Pressure | |||
| Systolic (mm Hg) | 129.3 ± 12.3 | 129.6 ± 14.4 | 0.93 |
| Diastolic (mm Hg) | 75.6 ± 10.7 | 73.4 ± 12.5 | 0.79 |
|
| |||
| Lab Values | |||
| Fasting Plasma Insulin (μU/ml) | 15.6 ± 8.1 | 18.2 ± 11.6 | 0.33 |
| 2-hour OGTT Insulin (μU/ml) (3) | 61.0 (18,226) | 77.5 (14,483) | 0.32 |
| FPG (mg/dL) | 103.8 ± 10.8 | 98.9 ± 9.0 | 0.06 |
| 2-hour OGTT Glucose (mg/dL) | 131.8 ± 41.9 | 125.8 ± 30.0 | 0.53 |
| HOMA-IR (2) | 4.0 ± 2.0 | 4.4 ± 2.7 | 0.54 |
| Whole blood HbA1c (%) | 5.7 ± 0.4 | 5.7 ± 0.5 | 0.90 |
| Serum total Cholesterol (mg/dL) | 187.8 ± 26.5 | 185.0 ± 36.4 | 0.73 |
| Serum HDL (mg/dL) | 51.7 ± 11.6 | 45.0 ± 11.6 | 0.03 |
| Serum LDL (mg/dL) | 112.0 ± 26.5 | 116.2 ± 29.2 | 0.56 |
| Serum Triglycerides (mg/dL) | 120.1 ± 49.3 | 120.5 ± 48.2 | 0.98 |
| Urine microalbumin (3) | 5.6 (0.0, 90.1) | 7.1 (0.0,57.8) | 0.24 |
| Serum creatinine (mg/dL) | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.53 |
|
| |||
| Endothelial function | |||
| FMD Pre OGTT (% Δ) | 7.8 ± 3.9 | 9.5 ± 4.7 | 0.15 |
| FMD Pre OGTT Nitro (% Δ) | 15.3 ± 5.7 | 16.2 ± 5.9 | 0.56 |
| FMD Post OGTT (% Δ) | 9.5 ± 4.5 | 10.2 ± 5.0 | 0.56 |
| SARM Pre OGTT (4) | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.50 |
| SARM Post OGTT (4) | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.42 |
1
Metabolic syndrome as defined by NCEP-ATP III criteria.
2
Homeostasis Model Assessment Insulin Resistance (HOMA-IR) by using the mathematical approximation, HOMA-IR = fasting plasma insulin (mU/mL) × fasting plasma glucose (mmol/L)/22.5.
3
Values are expressed as median (minimum, maximum).
4
SARM = stimulus-adjusted response measure.