Figure 3. Mitochondrial DNA mutations in human colorectal epithelium of subjects below 26 years of age (n = 8) and over 70 years of age (n = 8) measured by Next Generation Sequencing (NGS).

(A) MtDNA mutation frequency. There was a significantly higher mutation frequency in the subjects >70 years (p = 0.0361, unpaired t-test). (B) Types of mutations detected by NGS frequency. There was no significant difference in the types of mutations detected in subjects <26 and >70 years of age (p = 1.00, Fisher's exact test).