Table 5.
Averages and standard deviations of the repression activity of wild type and SHP mutants on HNF4α mediated transactivation of the ApoCIII promoter luciferase reporter
| pApoCIII-Luc. | Average (Luc/β-gal) | SD |
|---|---|---|
| HNF4α | 0.540 | 0.034 |
| HNF4α + SHPwt | 0.304 | 0.014 |
| HNF4α + Trp148Ala | 0.259 | 0.043 |
| HNF4α + Phe96Ala | 0.633 | 0.047 |
| HNF4α + Arg238Ala | 0.244 | 0.011 |
| HNF4α + Arg138Ala | 0.325 | 0.033 |
| HNF4α + Trp92Ala | 0.349 | 0.010 |
| HNF4α + Arg138Asp − Arg238Asp | 0.592 | 0.003 |
| HNF4α + Arg34Ala | 0.232 | 0.004 |
| HNF4α + Arg34Gln − Gln134Arg | 0.279 | 0.011 |