Table 4.

Subtype of Neuropathological Diagnosis for 12 National Alzheimer's Coordinating Center Subjects with Frontotemporal Lobar Degeneration (FTLD) and Moderate or Frequent CERAD Neuritic Plaque Densities But Not Meeting Neuropathological Definition of Alzheimer Disease Dementia

Subtype of frontotemporal lobar degeneration	Number of subjects
Hippocampal sclerosis	3
Pick disease	2
FTLD with ubiquitin-positive, tau-negative inclusions	2
FTLD with tau-positive or argyrophilic inclusions	1
Tangle-predominant dementia or argyrophilic grain dementia	1
FTLD with no distinctive histology	1
FTLD with “lower motor neuron pathology”	1
Corticobasal degeneration	1

Subjects had moderate or frequent CERAD neuritic plaque densities but did not meet neuropathological definition of Alzheimer Disease because of a Braak neurofibrillary stage less than III (based on majority read data). See Table 3 for other diagnostic categories.

CERAD, Consortium to Establish a Registry for Alzheimer's Disease; FTLD, frontotemporal lobar degeneration; NACC, National Alzheimer's Coordinating Center, University of Washington, Seattle, WA.