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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jul 5;1841(10):1403–1412. doi: 10.1016/j.bbalip.2014.06.012

Figure 2. Hypothetical mechanism for greater S1PR1 recycling in response to HDL–S1P.

Figure 2

Following activation of S1PR1 by albumin–S1P or HDL–S1P, S1PR1 is targeted for internalization and degradation by the proteasome. We speculate that HDL recruits factors such as NHERF-2 to the S1PR1 complex, thereby targeting S1PR1 to recycling endosomes. HDL might induce recruitment of such factors in S1PR1 recycling through its lipid transport activity. To contrast the mechanistic insights supported by experimental evidence with our speculations, we identify the components of our hypothetical mechanism by asterisks.