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. Author manuscript; available in PMC: 2015 Oct 21.
Published in final edited form as: Chem Commun (Camb). 2014 Oct 21;50(82):12293–12296. doi: 10.1039/c4cc05901h

Table 2.

Scope of Indoles 8a

Entry Substrate Product Yield (%)b
1 graphic file with name nihms625527t1.jpg
8a
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9a
73
2 graphic file with name nihms625527t3.jpg
8b
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9b
75
3 graphic file with name nihms625527t5.jpg
8c
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9c
77
graphic file with name nihms625527t7.jpg graphic file with name nihms625527t8.jpg
4 8d, R = OMe 9d 95
5 8e, R = Me 9e 68
6 8f, R = Cl 9f 63
7 8g, R = F 9g 70
graphic file with name nihms625527t9.jpg graphic file with name nihms625527t10.jpg
8 8h, R = Me 9h 70
9 8i, R = F 9i 70
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10 8j, R = Me 9j 67
11 8k, R = Cl 9k 65
12 8l, R = F 9l 81
13 graphic file with name nihms625527t12.jpg
8m
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9m
71
14 graphic file with name nihms625527t14.jpg
8n
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10
78
15 graphic file with name nihms625527t16.jpg
8o
no reaction
16 graphic file with name nihms625527t17.jpg
8p
no reaction
17 graphic file with name nihms625527t18.jpg
8q
no reaction
a

Conditions: 7 (1 equiv), indole 8 (2 equiv), Cu(CH3CN)4PF6 (10 mol %), 60 °C, ClCH2CH2Cl.

b

Isolated yield.