Table 2.
Scope of Indoles 8a
| Entry | Substrate | Product | Yield (%)b |
|---|---|---|---|
| 1 |
![]() 8a |
![]() 9a |
73 |
| 2 |
![]() 8b |
![]() 9b |
75 |
| 3 |
![]() 8c |
![]() 9c |
77 |
|
|
||
| 4 | 8d, R = OMe | 9d | 95 |
| 5 | 8e, R = Me | 9e | 68 |
| 6 | 8f, R = Cl | 9f | 63 |
| 7 | 8g, R = F | 9g | 70 |
|
|
||
| 8 | 8h, R = Me | 9h | 70 |
| 9 | 8i, R = F | 9i | 70 |
|
|||
| 10 | 8j, R = Me | 9j | 67 |
| 11 | 8k, R = Cl | 9k | 65 |
| 12 | 8l, R = F | 9l | 81 |
| 13 |
![]() 8m |
![]() 9m |
71 |
| 14 |
![]() 8n |
![]() 10 |
78 |
| 15 |
![]() 8o |
no reaction | |
| 16 |
![]() 8p |
no reaction | |
| 17 |
![]() 8q |
no reaction |
Conditions: 7 (1 equiv), indole 8 (2 equiv), Cu(CH3CN)4PF6 (10 mol %), 60 °C, ClCH2CH2Cl.
Isolated yield.












