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. 2014 Sep 18;10(9):e1004640. doi: 10.1371/journal.pgen.1004640

Figure 1. Local duplications in β-lactamase PenA.

Figure 1

A. Map of the peptides subjected to duplication and pairs of small nucleotide sequences that apparently mediated the underlying DNA duplication (formation of TRs). The entire omega loop is displayed at the top with the amino acids denoted using the one-letter codes and positions numbered according to Ambler et al. [47]. Direct repeats or same-strand complementary sequences (SCSs) associated with each DNA template are denoted by pink or blue boxes, respectively, and matching positions between the pair of SCSs are denoted with red dots. Green horizontal bars underneath denote the ends of the DNA templates. B. SCSs associated with the TRs in β-lactamase genes from clinical isolates. The SCSs identified in two β-lactamase genes with TR mutations, SHV-16 gene from K. pneumoniae and ampC from Enterobacter cloacae GC1, are shown in boxes. Below of each of the genes are their parental alleles, the SHV-1 gene and ampC in E. cloacae strain P99, respectively. The paired upstream and downstream elements are denoted in blue boxes.