Figure 3. Effect of cisplatin and paclitaxel treatment in NSUN2 and METTL1 knockdown and double knockdown cells.

(A) Dose-dependent cell survival in response to cisplatin in NSUN2 and METTL1 knockdown cells (open circle) and control vector-transfected cells (closed circle) with the MTT viability assay. There was no significant difference in survival of NSUN2 and METTL1 knockdown cells compared with control vector-transfected cells in all of each concentration. (B) Comparison of the average IC₅₀ values for cisplatin between NSUN2 and METTL1 knockdown cells and control vector-transfected cells. NS, not significant. (C) Dose-dependent cell survival in response to paclitaxel in NSUN2 and METTL1 knockdown cells (open circle) and control vector-transfected cells (closed circle) with the MTT viability assay. There was no significant difference in survival of NSUN2 and METTL1 knockdown cells compared with control vector-transfected cells in all of each concentration. (D) Comparison of the average IC₅₀ values for paclitaxel between NSUN2 and METTL1 knockdown cells and control vector-transfected cells. NS, not significant.