Table 3. Results of the hyperopia analyses in the regions that were significantly associated with myopia age at onset by Kiefer et al. [18] showing meta-analysis association results for each chosen SNP.
| Replication SNP1 | Chromosome | Position | Replication P value2 | Best SNP3,6 | Offset4,6 | P value5,6 | Nearest Gene(s)7 | Reported by Verhoeven et al. |
| rs6702767 | 1 | 200844547 | 1.60E-01 | rs6703834 | 264384 | 4.58E-03 | No | |
| rs11681122 | 2 | 146786063 | N/A | rs17412774 | 12116 | 1.50E-04 | No | |
| rs17428076 | 2 | 172851936 | 6.43E-03 | rs3821093 | 157350 | 2.44E-04 | No | |
| rs1898585 | 2 | 178660450 | N/A | rs6718702 | 84399 | 1.47E-05 | PDE11A | No |
| rs1550094 | 2 | 233385396 | N/A | rs1881494 | 12631 | 4.63E-05 | PRSS56 | Yes |
| rs1843303 | 3 | 4185124 | 1.98E-05 | rs795294 | 826 | 1.18E-05 | SUMF1/SETMAR | No |
| rs7624084 | 3 | 141093285 | N/A | rs9821337 | 2901 | 1.88E-04 | No | |
| rs1031004 | 4 | 80516849 | N/A | rs1371993 | 35034 | 1.13E-05 | GK2 (MIM:137028) | No |
| rs5022942 | 4 | 81959966 | N/A | rs2201544 | 30290 | 4.94E-03 | Yes | |
| rs7744813 | 6 | 73643289 | 7.00E-08 | KCNQ5 | No | |||
| rs12193446 | 6 | 129820038 | 1.84E-07 | LAMA2 | Yes | |||
| rs9365619 | 6 | 164251746 | 2.67E-01 | rs2759387 | 412079 | 9.50E-03 | No | |
| rs2137277 | 8 | 40734662 | 2.72E-02 | rs6474290 | 94596 | 2.42E-03 | Yes | |
| chr8:60178580 | 8 | 60178580 | N/A | rs10089517 | 141 | 1.82E-11 | TOX | Yes |
| rs10963578 | 9 | 18338649 | N/A | rs10115405 | 17893 | 2.54E-04 | No | |
| rs11145746 | 9 | 71834380 | 8.33E-03 | rs10481782 | 22378 | 2.71E-04 | No | |
| rs4245599 | 10 | 60365755 | 1.16E-03 | rs1866168 | 4194 | 8.11E-04 | Yes | |
| rs6480859 | 10 | 79081948 | 1.45E-02 | rs16933964 | 457642 | 4.35E-04 | No | |
| rs745480 | 10 | 85986554 | 3.26E-01 | rs17103281 | 25190 | 1.06E-04 | No | |
| rs4367880 | 10 | 114795256 | N/A | rs7914029 | 215000 | 3.40E-04 | No | |
| rs11602008 | 11 | 40149305 | N/A | rs10837366 | 75045 | 7.61E-05 | LRRC4C (MIM:608817) | No |
| chr11:65348347 | 11 | 65348347 | N/A | rs11820062 | 81589 | 7.56E-03 | No | |
| rs10736767 | 11 | 84637065 | 1.99E-01 | rs10898278 | 303825 | 3.05E-03 | No | |
| rs6487748 | 12 | 9435768 | N/A | rs7305636 | 157088 | 9.29E-04 | No | |
| rs3138142 | 12 | 56115585 | 4.32E-02 | rs12828230 | 230568 | 5.87E-04 | No | |
| rs4291789 | 13 | 100672921 | N/A | rs1347190 | 24823 | 6.65E-06 | ZIC2/ZIC5 | Yes |
| rs61988414 | 14 | 42313443 | N/A | rs10149831 | 125528 | 1.35E-03 | No | |
| chr14:54413001 | 14 | 54413001 | N/A | rs17127526 | 444960 | 1.26E-03 | No | |
| rs524952 | 15 | 35005886 | 3.07E-08 | rs11073060 | 16036 | 9.11E-11 | GJD2 | Yes |
| rs4778882 | 15 | 79382019 | N/A | rs1443658 | 4348 | 2.88E-03 | No | |
| rs17648524 | 16 | 7459683 | 4.86E-07 | RBFOX1 | Yes | |||
| rs2908972 | 17 | 11407259 | 1.39E-04 | rs12602611 | 166838 | 1.26E-05 | SHISA6 | No |
| rs10512441 | 17 | 31239645 | 4.78E-03 | rs17183113 | 210521 | 2.40E-03 | No | |
| rs9902755 | 17 | 47220726 | 2.81E-01 | rs8064938 | 439898 | 1.73E-03 | No | |
| chr17:79585492 | 17 | 79585492 | N/A | rs6565596 | 60374 | 1.13E-02 | No |
1. SNPs which are either genome-wide significant or meet our replication threshold are highlighted in bold text. Allele frequencies for these SNPs in each of our discovery populations can be found in Table S8.
2. For each SNP reported by Kiefer et al. , Replication P value is the P value of that SNP in our analysis. If that SNP was not genotyped or imputed in our data, it is indicated with N/A.
3. For regions where the most significant SNP in our analysis is not the original reported SNP, that SNP is reported as Best SNP.
4. Offset is the absolute distance in base pairs to the original SNP and the P value associated with Best SNP.
5. Z scores and direction of effect for all SNPs are in Table S2.
6. This column left blank where the original SNP is the most significant SNP in the region.
7. Nearest Gene(s) indicates the closest gene by physical position for these SNPs.