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. 2014 Sep 18;9(9):e101810. doi: 10.1371/journal.pone.0101810

Figure 6. Frequency-modulated (FM) noise based reconstructions.

Figure 6

a) Jarzynski PMF estimates based on the FM stochastic perturbation protocol. The external Gaussian noise was applied with the 10 m/s pulling velocity, using four noise amplitudes, m = 180, 190, 200 and 210. b) Second order cumulant expansion PMF estimates based on the FM stochastic perturbation protocol. The chi-square noise was applied to 10 m/s pulling velocity using 4 different noise amplitudes, m = 100, 110, 120 and 130. The estimates based on the normal pulling (1 m/s and 10 m/s) are given for the comparison. In each case depicted the computational cost is the same, i.e., it is analogous to the cost required to generate 10,000 trajectories using the normal pulling and 10 m/s velocity.