Skip to main content
. 2014 Sep 18;9(9):e107556. doi: 10.1371/journal.pone.0107556

Figure 4. LPS increases NOX2 in 1–2 weeks.

Figure 4

Cardiac expression of mediators of fibrosis (mean + SEM) measured by QRT-PCR in mice injected with i.p. saline (Control, n = 7), or LPS 10 mg/kg/week for 1 week (n = 6) or for 2 weeks (n = 6). LPS significantly increased NOX2 (P = 0.002) and IL-6 (P = 0.039, one way ANOVA), but not NOX4, transforming growth factor- β (TGF-β) or connective tissue growth factor (CTGF) (all P = ns). There was a tendency for LPS to decrease SOD2 (P = 0.057). Multiple comparisons (Holm-Sidak Test) showed that compared with control, there were significant increases in NOX2 at 1 week or 2 weeks and IL-6 at 2 weeks (*P<0.05), with no difference between 1 or 2 weeks.