Table 1. Time course for changes in fibrosis related factors in the left ventricle after injection of LPS (10 mg/kg/week i.p.) compared with control (saline injection).
| 3 days | 1 week | 2 weeks | |
| collagen fraction area | no change | Increase | |
| miR-29c | Decrease | Decrease | |
| IL-6 | Increase | no change | Increase |
| NOX2 | Increase | Increase | Increase |
| TIMP1 | Increase | Increase | Increase |
| TIMP2 | no change | Increase | Increase |
| MMP2 | no change | Increase | Increase |
| MMP9 | no change | Increase | |
| collagen I α1 | no change | Increase | Increase |
| collagen III α1 | no change | Increase | Increase |
| periostin | no change | Increase | Increase |
NOX 2 = NADPH Oxidase 2, MMP = matrix metaloproteinase, TIMP = tissue inhibitors of MMPs.