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. 2014 Sep 18;9(9):e107853. doi: 10.1371/journal.pone.0107853

Table 2. Genes expression from protocol 2 (fold changes).

Groups 10 week of age 20 week of age
E-cadherin FSP-1 Sgk-1 NHE-1 E-cadherin FSP-1 Sgk-1 NHE-1
DSS + NS 1.00±0.04 1.00±0.06 1.00±0.1 1.00±0.09 1.00±0.02 1.00±0.12 1.00±0.12 1.00±0.0
DSS + HS 0.52±0.30a 2.42±0.15a 2.33±0.11a 1.99±0.04a 0.41±0.02a 3.15±0.24a,# 2.99±0.10a 2.10±0.09a
DSS + HS → NS - - - - 0.48±0.03b 2.33±0.06b 2.38±0.11 1.80±0.17
DSS + HS → NS + OLM - - - - 0.73±0.05c 1.37±0.09c 1.37±0.05c 1.25±0.06c
DSS + HS → NS + AZEL - - - - 0.6±0.04 1.50±0.49c 1.35±0.79c 1.26±0.08c
DSS + HS → NS + OLM + AZEL - - - - 0.95±0.02c,d 1.10±0.02c,d 1.03±0.08c,d 0.99±0.25c
DSS + HS → NS + HYD - - - - 0.52±0.06 2.10±0.22 2.18±0.16 1.73±0.10

FSP-1; fibroblast-specific protein-1, Sgk-1; serum and glucocorticoid-regulated kinases-1, NHE-1; Na+/H+ exchanger isoform-1, DSS; Dahl salt-sensitive rats, NS; normal salt (0.5% NaCl), HS; High salt (4% NaCl), OLM; olmesartan, AZEL; azelnidipine, HYD; hydralazine. β-actin was used as an internal control and results are expressed as fold changes to 10-week values of the DSS + NS group. # P<0.05 vs. 10-week values of the DSS + HS group. a P<0.05 vs. DSS + NS, b P<0.05 vs. DSS + HS, c P<0.05 vs. DSS + HS → NS, d P<0.05 vs. DSS + HS → NS + OLM or DSS + HS → NS + AZEL.