Table 2. Genes expression from protocol 2 (fold changes).
Groups | 10 week of age | 20 week of age | ||||||
E-cadherin | FSP-1 | Sgk-1 | NHE-1 | E-cadherin | FSP-1 | Sgk-1 | NHE-1 | |
DSS + NS | 1.00±0.04 | 1.00±0.06 | 1.00±0.1 | 1.00±0.09 | 1.00±0.02 | 1.00±0.12 | 1.00±0.12 | 1.00±0.0 |
DSS + HS | 0.52±0.30a | 2.42±0.15a | 2.33±0.11a | 1.99±0.04a | 0.41±0.02a | 3.15±0.24a,# | 2.99±0.10a | 2.10±0.09a |
DSS + HS → NS | - | - | - | - | 0.48±0.03b | 2.33±0.06b | 2.38±0.11 | 1.80±0.17 |
DSS + HS → NS + OLM | - | - | - | - | 0.73±0.05c | 1.37±0.09c | 1.37±0.05c | 1.25±0.06c |
DSS + HS → NS + AZEL | - | - | - | - | 0.6±0.04 | 1.50±0.49c | 1.35±0.79c | 1.26±0.08c |
DSS + HS → NS + OLM + AZEL | - | - | - | - | 0.95±0.02c,d | 1.10±0.02c,d | 1.03±0.08c,d | 0.99±0.25c |
DSS + HS → NS + HYD | - | - | - | - | 0.52±0.06 | 2.10±0.22 | 2.18±0.16 | 1.73±0.10 |
FSP-1; fibroblast-specific protein-1, Sgk-1; serum and glucocorticoid-regulated kinases-1, NHE-1; Na+/H+ exchanger isoform-1, DSS; Dahl salt-sensitive rats, NS; normal salt (0.5% NaCl), HS; High salt (4% NaCl), OLM; olmesartan, AZEL; azelnidipine, HYD; hydralazine. β-actin was used as an internal control and results are expressed as fold changes to 10-week values of the DSS + NS group. # P<0.05 vs. 10-week values of the DSS + HS group. a P<0.05 vs. DSS + NS, b P<0.05 vs. DSS + HS, c P<0.05 vs. DSS + HS → NS, d P<0.05 vs. DSS + HS → NS + OLM or DSS + HS → NS + AZEL.