Table 3. Number of Pregnancies in relation to dosing and parental treatment at the first and repeat mating to produce the F₁ generation.

Drug	Dose (mg/kg)	Dam Sample size (n)	aPregnancies at First mating		bPregnancies at Repeat mating
			Father-only	Both-parents	Father-only	cBoth-parents
ZDV	10	10	3	7	2	2
	100	10	2	1	2	1
	250	10	1	4	1	2
NVP	5	10	2	6	2	0
	50	10	2	5	5	4
	150	10	0	9	2	2
Total			10	32	14	11

Four males per dose mated with five females each to give a total of twenty females per dose. Ten of these females were untreated (“father-only” treated groups) while the other ten had received the same dose as the males (“both-parents” treated groups) for 56 days before mating. Harem mating was done by co-housing one male and five females for 10 days without checking for vaginal plugs.

ZDV = Zidovudine; NVP = Nevirapine.

^aPregnancies observed when all males were on therapy at the time of mating.

^bPregnancies observed when all males have been withdrawn from therapy for one spermatogenic cycle (56 days) before mating the same set of dams again.

^cBoth parents had been on therapy but at repeat mating, only the dams were currently on therapy as the males had been withdrawn for one full spermatogenic cycle.

Using the Fisher’s Exact Chi-squared test, there was no significant different in the pregnancies recorded by dose and also no significant difference in pregnancies observed for the “father-only” and “both-parents” groups.