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. 2014 Sep 18;9(9):e108157. doi: 10.1371/journal.pone.0108157

Figure 3. Effect of fucoidan on the relative phosphorylation of CaMKII (p-CaMKII/CaMKII) and Bax expression in MDA-MB-231 cells (A) and HCT116 cells (B).

Figure 3

(A) Relative phosphorylation of CaMKII and Bax expression were progressively increased by fucoidan in MDA-MB-231 cells; (B) Relative phosphorylation of CaMKII was moderately stimulated (∼1.5-fold) at 10 µg/ml, followed by inhibition (∼1.4-fold) of fucoidan at 100 µg/ml. Bax expression was not affected by fucoidan in HCT116 cells. (C) Caspase 12 expression and cleavage. Fucoidan efficiently induces caspase 12 expression in MDA-MB-231 cells, rather than in HCT116 cells. No cleavage of caspase 12 was found in both types of cells. Data represent mean ± SD from triplicate experiments. *p<0.05; **p<0.01.