Figure 5. Fucoidan activates p-eIF2α\CHOP in MDA-MB-231 cells (A) and HCT116 cells (B).

Cells were treated with fucoidan as described in the “Materials and Methods” and in Figure 2. The relative phosphorylation of eIF2α (p-eIF2α/eIF2α) and CHOP expression were remarkably increased by fucoidan as assessed by immunoblot. TG treatment (2.0 µM, 24 h) induced activation of p-eIF2α and CHOP expression. Data are expressed as mean ± SD in triplicate experiments. *p<0.05; **p<0.01.