Skip to main content
. 2014 Sep 18;9(9):e108071. doi: 10.1371/journal.pone.0108071

Figure 1. Schematic diagram and abbreviation of Ad5, Ad35 and Ad28.

Figure 1

Schematic diagram comparing similar regions in Ad5, Ad35 and Ad28 vectors (A). The E1 region has been deleted in each construct and replaced with the SV40 poly A region, the luciferase or green fluorescent protein cDNA, and the cytomegalovirus promoter (CMV). In the Ad5 vector, there is a partial E3 deletion and the E4 region was replaced with a transcriptionally inert sequence. In the Ad35 and Ad28 vectors, the E3 regions and E4 regions are intact. The genomes of all vectors are approximately the same size. Plus in the vector abbreviation means RGD motif incorporation in the fiber knob. Ad5+ alone has also been deleted for the RGD motif in the penton base (B).