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. 2014 Sep 18;9(9):e108071. doi: 10.1371/journal.pone.0108071

Figure 5. Luciferase activity following a single subretinal injection of Ad5-Luc, Ad35-Luc and Ad28-Luc.

Figure 5

Ad5-Luc expression peaked one day after injection, but thereafter decreased quickly. Ad35-Luc expression peaked at seven days after injection and remained elevated out to 6 months. Ad35-Luc expression was significantly stronger than Ad5-Luc at the time point of 28 days and 6 months (p = 0.0127*, 0.033‡, respectively). Ad28-Luc expression was substantial and was sustained throughout one month of observation, but was low at 6 months. Ad28-Luc expression was significantly stronger than Ad5-Luc at 28 days after injection (p = 0.0127†). Error bars: SEM. n = 4 to 6/vector/time point. Which are Ad5-1day 4eyes, Ad35-1day 5 eyes, Ad28-1day 4 eyes, Ad5-7days 5 eyes, Ad35-7days 4 eyes, Ad28-7days 5 eyes, Ad5-14days 4 eyes, Ad35-14days 5 eyes, Ad28-14days 4 eyes, Ad5-28days 5 eyes, Ad35-28days 4 eyes, Ad28-28days 4 eyes, Ad5-6months 6 eyes, Ad35-6months 4 eyes, Ad28-6months 6 eyes.