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. 2014 Sep 18;9(9):e108071. doi: 10.1371/journal.pone.0108071

Table 1. Summary of the localization and duration of transgene expression.

Route of administration Abbreviation Localization Duration of transgene expression
Intravitreous injection Ad5- Corneal endothelial cells,Trabecular cells, Iris cells Peaked within one day post injection
Intravitreous injection Ad35- Trabecular cells Peaked within one day post injection
Intravitreous injection Ad28- Corneal endothelial cells,Trabecular cells, Iris cells Peaked within one day post injection
Subretinal injection Ad5- Photoreceptors, RPE cells(stronger GFP fluorescencein the RPE cells) Peaked one day after injection, but decreased quickly
Subretinal injection Ad35- Photoreceptors, RPE cells Peaked at seven days after injection and remained elevated out to 6 months
Subretinal injection Ad28- RPE cells Substantial and sustained throughout one month, but low at 6 months